In the late 1990s, the World Health Assembly adopted resolutions targeting the global elimination of the diseases lymphatic filariasis (LF) and trachoma as public health problems. Tremendous progress has been made since then, with 19 countries eliminating LF and 18 countries eliminating trachoma.To validate elimination of a neglected tropical disease (NTD) as a public health problem, World Health Organization (WHO) Member States must follow a standardized five-step process to summarize their achievements in a dossier. Since 2014, USAID has supported Ministries of Health (MOH) in the preparation and submission of dossiers. This support has resulted in dossier submission and validation of elimination by WHO in Bangladesh (LF), Cambodia (trachoma), Nepal (trachoma), People’s Democratic Republic of Lao (LF and trachoma) and Viet Nam (LF). Act | East has also helped governments prepare draft dossiers for LF or trachoma in an additional 7 countries. These countries’ experiences developing and submitting dossiers underscore the importance of initiating data compilation early, strategizing to address remaining data gaps, and planning for government review and approval. This brief provides a summary of best practices and common challenges for countries preparing dossiers—lessons gathered from dossier submission work in Act | East supported countries.